尤进茂

尤进茂：

教授，博士生导师

中国科学院兰州化学物理研究所理学博士学位；

中国科学院百人计划择优支持；

青海省昆仑学者特聘教授；

绍兴文理学院化学化工学院教授；

国家科学技术奖励评审委员;

国家科学技术奖励评审专家

主要从事液相色谱/质谱、电泳、荧光发光材料分子探针的制备，从事质谱条件下的蛋白质组学、代谢组学、糖组学研究；从事特色资源植物药用开发、稳定同位素标记、样品前处理及色谱-质谱新方法的建立，开展药代动力学、药物分析、质谱裂解规律等方面的研究工作。

主持国家自然科学基金面上项目4项；主持科技部农社口科技人员服务企业行动项目1项；主持省部共建三江源生态与高原农牧业国家重点实验室开放课题1项；主持山东省自然科学基金面上项目1项、奖励基金1项；负责青海省星火计划1项；负责中国科学院西部之光项目2项；2010年获中国科学院“百人计划”择优支持。

以通讯作者或第一作者发表SCI论文350余篇，申请专利40余项 。获得国家科技进步二等奖1项；省级教学成果奖二等奖1项；省级自然科学二等奖1项和省科技进步一等奖2项；山东省高等学校优秀科研成果一等奖1项、二等奖3项三等奖1项；培养博士研究生10余人（获中国科学院院长奖学金优秀奖6人）、培养硕士研究生80余名。

2006-2021年，担任山东省生命有机分析重点实验室主任；2011-2021，担任山东省绿色天然产物及医药中间体开发高校重点实验室主任；济宁市优秀科技创新团队带头人；

近期发表的代表性论文：

1 Colorimetric detection of heavy metal ions with various chromogenic

materials: Strategies and applications Chen, Zhuo; Zhang, Zhiyang; Qi, Ji; You, Jinmao; Ma, Jiping; Chen, Lingxin Journal of Hazardous Materials, 2023, 441: 129889 JCR一区（14.224）

2 Electronic tuning strategy in H2S-triggered fluorescence sensing and

subsequent photodynamic therapy of colon cancer Tan, Jiangkun; Lu, Zhihao; Gao, Chunyu; Zhang, Zhuoyue; Sun, Ziyan; Ling, Baoping; Li, Zan; You, Jinmao Dyes and Pigments, 2023, 213: 111199 JCR一区（5.122）

3 Nonoxidative Strategy for Monitoring Peroxynitrite Fluctuations in

Immune Responses of Tumorigenesis Lu, Jiao; Li, Zan; Gao, Qing; Tan, Jiangkun; Sun, Zhiwei; Chen, Lingxin; You, Jinmao Analytical Chemistry, 2021, 93: 3426−3435 JCR一区(6.785)

4 Construction of ultrasensitive devices for visualization and quantification of

phosgene based on FRET-mediated two-photon chemosensor Tan, Jiangkun; Li, Zan; Yao, Wen; Ji, Zhongyin; Sun, Zhiwei; You, Jinmao Dyes and Pigments, 2021, 187: 109138 JCR一区（5.122）

5 Recent progress in the development of chemodosimeters for fluorescence

visualization of phosgene Tan, Jiangkun; Li, Zan; Lu, Zhihao; Chang, Rui; Sun, Zhiwei; You, Jinmao Dyes and Pigments, 2021， 193: 109540 JCR一区（5.122）

6 A rapid response near-infrared ratiometric

fluorescent probe for the real-time tracking

of peroxynitrite for pathological diagnosis and

therapeutic assessment in a rheumatoid arthritis

model Lu, Jiao; Li, Zan; Zheng, Xinrui; Tan, Jiangkun; Ji, Zhongyin; Sun, Zhiwei; You, Jinmao Journal of

Materials Chemistry B, 2020, 8: 9343 JCR二区（7.571）

7 Imaging of the mutual regulation between zinc cation and nitrosyl via two-photon fluorescent probes in cells and in vivo Li, Mingshun; Xing, Yanlong; Zou, Yuxia; Chen, Guang; You, Jinmao; Yu, Fabiao Sensors and Actuators B: Chemical, 2020, 309: 127772. JCR 一区(7.1)

8 Permanently Positively Charged Stable Isotope Labeling Agents and Its Application in the Accurate Quantitation of Alkylphenols Migrated from

Plastics to Edible Oils Ma, Chong; Zhang, Shijuan; Wu, Xia; You, Jinmao Journal of Agricultural and Food Chemistry, 2020, 68, 33, 9024–9031 JCR一区（5.895）

9 Dual lanthanide-probe based on coordination polymer networks for ratiometric detection of glyphosate in food samples Qu, Fei; Wang, Han; You, Jinmao Food Chemistry, 2020: 126815. JCR 一区(6.306)

10 Cationic Surfactant Modified 3D COF and Its Application in the Adsorption of UV Filters and Alkylphenols from Food Packaging Material Migrants Zhang, Shijuan; Wu, Xia; Ma, Chong; Li, Yanxin; You, Jinmao Journal of Agricultural and Food Chemistry, 2020, 68(11): 3663-3669. JCR 一区(4.192)

11 Detection of Selenocysteine with a Ratiometric near-Infrared Fluorescent Probe in Cells and in Mice Thyroid Diseases Model Luo, Xianzhu; Wang, Rui; Lv, Chuanzhu; Chen, Guang; You, Jinmao; Yu, Fabiao Analytical Chemistry, 2019, 92(1): 1589-1597. JCR一区(6.785)

12 A highly sensitive near-infrared ratiometric fluorescent probe for imaging of mitochondrial hydrazine in cells and in mice models Song, Yaqun; Chen, Guang; Han, Xiaoyue; You, Jinmao; Yu, Fabiao Sensors and Actuators B-chemical, 2019: 69-76. JCR 一区(7.1)

13 External Reductant-Free Palladium-Catalyzed Reductive Insertion of Isocyanide: Synthesis of Polysubstituted Pyrroles and Its Applications as a Cysteine Probe Chen, Dianpeng; Shan, Yingying; Li, Jianming; You, Jinmao; Sun, Xuejun; Qiu, Guanyinsheng Organic Letters, 2019, 21(11): 4044-4048. JCR 一区IF=6.091

14 Polystyrene Encapsulated SERS Tags as Promising Standard Tools: Simple and Universal in Synthesis; Highly Sensitive and Ultrastable for Bioimaging Yu, Qian; Wang, Yunqing; Mei, Rongchao; Yin, Yingchao; You, Jinmao; Chen, Lingxin Analytical Chemistry, 2019, 91(8): 5270-5277. JCR 一区(6.785)

15 Cationic gemini surfactant-resorcinol-aldehyde resin and its application in the extraction of endocrine disrupting compounds from food contacting materials Zhang, Shijuan; Xu, Ting; Liu, Qian; Liu, Jiammin; Lu, Fengli; Yue, MingBo; Li, Yanxin; Sun, Zhiwei; You, Jinmao Food Chemistry, 2019: 407-413. JCR 一区(6.306)

16 Ambient electrochemical N-2 reduction to NH3 under alkaline conditions enabled by a layered K2Ti4O9 nanobelt Wu, Dan; Wang, Huanbo; Huang, Hong; Zhang, Rong; Ji, Lei; Chen, Hongyu; Luo, Yonglan; You, Jinmao; Tang, Dianping; Zhang, Zhonghai; Sun, Xuping Chemical Communications, 2019, 55: 7546-7549 JCR 一区(5.996)

17 Design of a multifunctional biotinylated copper complex for visualization and quantification of cancer hypoxia levels Li, Zan; Zhu, Zhenzhu; Sun, Zhiwei; Ding, Jie; You, Jinmao Sensors and Actuators B-chemical, 2019: 541-548. JCR 一区(7.1)

18 A novel biomass-based reusable AIE material: AIE properties and potential applications in amine/ammonia vapor sensing and information storage Zhang, Ensheng; Hou, Xiufang; Zhang, ZE; Zhang, Yuqi; Wang, Jijiang; Yang, Hua; You, Jinmao; Ju, Ping Journal of Materials Chemistry C, 2019, 7(27): 8404-8411. JCR 一区(7.059)

19 Ratiometric Near-Infrared Fluorescent Probe for Synergistic Detection of Monoamine Oxidase B and Its Contribution to Oxidative Stress in Cell and Mice Aging Models Wang, Rui; Han, Xiaoyue; You, Jinmao; Yu, Fabiao; Chen, Lingxin Analytical Chemistry, 2018, 90(6): 40-54 JCR 一区(6.785)

20 Fluorescence turn-off Ag/fluorinated graphene composites with high NIR absorption for effective killing of cancer cells and bacteria Gong, Peiwei; Wang, Fei; Guo, Feifei; Liu, Jinfeng; Wang, Bin; Ge, Xingxing; Li, Shuohan; You, Jinmao; Liu, Zhe Journal of Materials Chemistry B, 2018, 6(47): 7926-7935. JCR 二区(5.334)

21 Ratiometric detection of Zn2+ and Cd2+ based on self-assembled nanoarchitectures with dual emissions involving aggregation enhanced emission (AEE) and its application Qu, Fei; Zhao, Lingyun; Han, Wenli; You, Jinmao Journal of Materials Chemistry B, 2018, 6(30): 4995-5002. JCR 二区(5.334)

22 Ultra-low loading of Ag3PO4 on hierarchical In2S3 microspheres to improve the photocatalytic performance: The cocatalytic effect of Ag and Ag3PO4 Yan, Tingjiang; Tian, Jun; Guan, Wenfei; Qiao, Zheng; Li, Wenjuan; You, Jinmao; Huang, Baibiao Applied Catalysis B-environmental, 2017, 202(202): 84-94. JCR 一区(16.683)

23 A novel dual-ratiometric-response fluorescent probe for SO2/ClO- detection in cells and in vivo and its application in exploring the dichotomous role of SO2 under the ClO- induced oxidative stress Dou, Kun; Fu, Qiang; Chen, Guang; Yu, Fabiao; Liu, Yuxia; Cao, Ziping; Li, Guoliang; Zhao, Xianen; Xia, Lian; Chen, Lingxin; Wang, Hua; You, Jinmao Biomaterials, 2017: 82-93. JCR 一区(10.317)

24 One-pot synthesis of magnetic iron oxide nanoparticle-multiwalled carbon nanotube composites for enhanced removal of Cr(VI) from aqueous solution Lu, Wenhui; Li, Jinhua; Sheng, Yanqing; Zhang, Xinshen; You, Jinmao; Chen, Lingxin Journal of Colloid and Interface Science, 2017: 1134-1146. JCR 二区(7.489)

25 Anion-exchange synthesis of Ag2S/Ag3PO4 core/shell composites with enhanced visible and NIR light photocatalytic performance and the photocatalytic mechanisms Tian, Jun; Yan, Tingjiang; Qiao, Zheng; Wang, Linlin; Li, Wenjuan; You, Jinmao; Huang, Baibiao Applied Catalysis B-environmental, 2017: 566-578. JCR 一区(16.683)

26 Towards the determination of sulfonamides in meat samples: A magnetic and mesoporous metal-organic framework as an efficient sorbent for magnetic solid phase extraction combined with high-performance liquid chromatography Xia, Lian; Liu, Lijie; Lv, Xiaoxia; Qu, Fei; Li, Guoliang; You, Jinmao Journal of Chromatography A, 2017: 24-31. JCR 二区(4.049)

27 A ratiometric fluorescent nanosensor for the detection of silver ions using graphene quantum dots Zhao, Xian-En; Lei, Cuihua; Gao, Yue; Gao, Han; Zhu, Shuyun; Yang, Xue; You, Jinmao; Wang, Hua Sensors and Actuators B-chemical, 2017: 239-246. JCR 一区(7.1)

28 Bright and sensitive ratiometric fluorescent probe enabling endogenous FA imaging and mechanistic exploration of indirect oxidative damage due to FA in various living systems Dou, Kun; Chen, Guang; Yu, Fabiao; Liu, Yuxia; Chen, Lingxin; Cao, Ziping; Chen, Tao; Li, Yulin; You, Jinmao Chemical Science, 2017, 8(11): 7851-7861. JCR 一区(9.346)

29 Wide-Acidity-Range pH Fluorescence Probes for Evaluation of Acidification in Mitochondria and Digestive Tract Mucosa Chen, Guang; Fu, Qiang; Yu, Fabiao; Ren, Rui; Liu, Yuxia; Cao, Ziping; Li, Guoliang; Zhao, Xianen; Chen, Lingxin; Wang, Hua; You, Jinmao Analytical Chemistry, 2017, 89(16): 8509-8516. JCR 一区(6.785)

30 Facile and Sensitive Fluorescence Sensing of Alkaline Phosphatase Activity with Photoluminescent Carbon Dots Based on Inner Filter Effect Li, Guoliang; Fu, Huili; Chen, Xuejie; Gong, Peiwei; Chen, Guang; Xia, Lian; Wang, Hua; You, Jinmao; Wu, Yongning Analytical Chemistry, 2016, 88(5): 2720-2726. JCR 一区(6.785)

31 A fluorescence resonance energy transfer (FRET) based "Turn-On" nanofluorescence sensor using a nitrogen-doped carbon dot-hexagonal cobalt oxyhydroxide nanosheet architecture and application to alpha-glucosidase inhibitor screening Li, Guoliang; Kong, Weiheng; Zhao, Mei; Lu, Shuaimin; Gong, Peiwei; Chen, Guang; Xia, Lian; Wang, Hua; You, Jinmao; Wu, Yongning Biosensors and Bioelectronics, 2016: 728-735. JCR 一区(10.257)

32 Facile and ultrasensitive fluorescence sensor platform for tumor invasive biomaker beta-glucuronidase detection and inhibitor evaluation with carbon quantum dots based on inner-filter effect Lu, Shuaimin; Li, Guoliang; Lv, Zhengxian; Qiu, Nannan; Kong, Weiheng; Gong, Peiwei; Chen, Guang; Xia, Lian; Guo, Xiaoxi; You, Jinmao; Wu, Yongning Biosensors and Bioelectronics, 2016: 358-362. JCR 一区(10.257)

33 Nanopore-Based Selective Discrimination of MicroRNAs with Single-Nucleotide Difference Using Locked Nucleic Acid-Modified Probes Xi, Dongmei; Shang, Jizhen; Fang, Enguo; You, Jinmao; Zhang, Shusheng; Wang, Hua Analytical Chemistry, 2016, 88(21): 10540-10546. JCR  一区(6.785)